F2r^tm2.1Jogr
Targeted Allele Detail

Summary

• Symbol: F2r^tm2.1Jogr
• Name: coagulation factor II thrombin receptor; targeted mutation 2.1, John H Griffin
• MGI ID: MGI:6781957
• Synonyms: QQ46-PAR1
• Gene: F2r Location: Chr13:95738311-95754995 bp, - strand Genetic Position: Chr13, 50.21 cM
• Alliance: F2r^tm2.1Jogr page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:261560
• Parent Cell Line: C2 (Nagy) (ES Cell)
• Strain of Origin: C57BL/6NTac

Mutation description

• Allele Type: Targeted (Not Applicable)
• Mutations: Insertion, Nucleotide substitutions
• Mutation details: A mutation was engineered in exon 2 to change arginine codon 46 (AGG) to a glutamine codon (CAG)(p.R46Q) and an FRT site flanked neomycin resistance gene cassette was inserted into intron 1. The neo cassette was removed through subsequent flp-mediated recombination. The mutation prevents cleavage at that residue by activated protein C (APC). (J:261560)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any F2r Mutation: 23 strains or lines available

References

• Original: J:261560 Sinha RK, et al., PAR1 biased signaling is required for activated protein C in vivo benefits in sepsis and stroke. Blood. 2018 Mar 15;131(11):1163-1171
• All: 5 reference(s)