Dmp1^tm1.1Zuw
Targeted Allele Detail

Summary

• Symbol: Dmp1^tm1.1Zuw
• Name: dentin matrix protein 1; targeted mutation 1.1, Zuolin Wang
• MGI ID: MGI:6781799
• Synonyms: S89G-DMP1
• Gene: Dmp1 Location: Chr5:104350479-104361968 bp, + strand Genetic Position: Chr5, 50.61 cM
• Alliance: Dmp1^tm1.1Zuw page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:278186
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Targeted (Not Applicable)
• Mutations: Insertion, Nucleotide substitutions
• Mutation details: Using BAC RP23-314P12, exon 6 was targeted for a mutation changing serine codon 89 to a glycin codon (p.S89G) and an FRT site flanked neomycin resistance gene cassette was inserted into intron 6. The neo cassette was removed through subsequent flp-meditaed recombination. This mutation prevents the glycosylation of the residue in the encoded peptide. (J:278186)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Dmp1 Mutation: 38 strains or lines available

References

• Original: J:278186 Sun Y, et al., Glycosylation of Dentin Matrix Protein 1 is critical for osteogenesis. Sci Rep. 2015 Dec 4;5:17518
• All: 5 reference(s)