Ripk2^em1Gpt
Endonuclease-mediated Allele Detail

Summary

• Symbol: Ripk2^em1Gpt
• Name: receptor (TNFRSF)-interacting serine-threonine kinase 2; endonuclease-mediated mutation 1, GemPharmatech Co., Ltd
• MGI ID: MGI:6781727
• Synonyms: Rip2^f, Ripk2^em1Cflox/Gpt
• Gene: Ripk2 Location: Chr4:16122733-16163647 bp, - strand Genetic Position: Chr4, 6.7 cM
• Alliance: Ripk2^em1Gpt page

Mutation origin

• Strain of Origin: C57BL/6JGpt

Mutation description

• Allele Type: Endonuclease-mediated (Conditional ready)
• Mutation: Insertion
• CRISPR-targeting floxed exons 2 of Ripk2 gene containing 154bp coding sequence. (J:293217)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ripk2 Mutation: 35 strains or lines available

References

• Original: J:309036 Zhou Y, et al., Hepatic NOD2 promotes hepatocarcinogenesis via a RIP2-mediated proinflammatory response and a novel nuclear autophagy-mediated DNA damage mechanism. J Hematol Oncol. 2021 Jan 7;14(1):9
• All: 2 reference(s)