Hecw1^tm1.1Fhe
Targeted Allele Detail

Summary

• Symbol: Hecw1^tm1.1Fhe
• Name: HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1; targeted mutation 1.1, Fuchu He
• MGI ID: MGI:6781648
• Synonyms: Nedl1^-, Nedl1^LacZ
• Gene: Hecw1 Location: Chr13:14401023-14697813 bp, - strand Genetic Position: Chr13, 5.29 cM
• Alliance: Hecw1^tm1.1Fhe page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:311917
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Using homologous recombination in ES cells, the targeting construct inserted FRT-IRES-LacZ-Loxp-neo-FRT-LoxP into the intron upstream of the exon 8, and an additional LoxP was inserted into the intron downstream of the exon 8. A cre mediated deletion removed neo-cassette-FRT-LoxP and exon 8 leaving FRT-IRES-LacZ-LoxP in the intron. (J:311917)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Hecw1 Mutation: 78 strains or lines available

References

• Original: J:311917 Qiu X, et al., NEDL2 regulates enteric nervous system and kidney development in its Nedd8 ligase activity-dependent manner. Oncotarget. 2016 May 24;7(21):31440-53
• All: 1 reference(s)