Tbr1^tm2.1Jlr
Targeted Allele Detail

Summary

• Symbol: Tbr1^tm2.1Jlr
• Name: T-box brain transcription factor 1; targeted mutation 2.1, John L Rubenstein
• MGI ID: MGI:6781264
• Synonyms: Tbr1^flox
• Gene: Tbr1 Location: Chr2:61633274-61644458 bp, + strand Genetic Position: Chr2, 35.56 cM
• Alliance: Tbr1^tm2.1Jlr page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:267864
• Parent Cell Line: iTL BA1 (ES Cell)
• Strain of Origin: (C57BL/6NTac x 129S6/SvEvTac)F1

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: The targeting construct floxed exons 2 and 3. Flp-mediated recombination removed the FRT-flanked neomycin resistance cassette inserted into intron 3. (J:267864)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Tbr1 Mutation: 38 strains or lines available

References

• Original: J:267864 Fazel Darbandi S, et al., Neonatal Tbr1 Dosage Controls Cortical Layer 6 Connectivity. Neuron. 2018 Nov 21;100(4):831-845.e7
• All: 3 reference(s)