Rac1^tm1.1Nesh
Targeted Allele Detail

Summary

• Symbol: Rac1^tm1.1Nesh
• Name: Rac family small GTPase 1; targeted mutation 1.1, Norman E Sharpless
• MGI ID: MGI:6781238
• Synonyms: Rac1(P29S)
• Gene: Rac1 Location: Chr5:143491236-143513786 bp, - strand Genetic Position: Chr5, 82.22 cM
• Alliance: Rac1^tm1.1Nesh page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:94077
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutations: Insertion, Single point mutation
• Mutation details: A targeting construct inserted a floxed unit containing the wild type exons 2-6, three stop codons, and a FRT-site flanked Neomycin resistant cassette. A modified exon 2 with a point mutation in exon 2 generating the amino acid substitution of proline for serine at position 29 (P29S) was inserted after the loxP sites. Flp-mediated recombination removed the selection cassette. (J:94077)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rac1 Mutation: 26 strains or lines available

References

• Original: J:94077 Mutant Mouse Regional Resource Centers, Information obtained from the Mutant Mouse Regional Resource Centers (MMRRC). Unpublished. 2004-2015
• All: 1 reference(s)