Ntrk1^tm1.2Tkato
Targeted Allele Detail

Summary

• Symbol: Ntrk1^tm1.2Tkato
• Name: neurotrophic tyrosine kinase, receptor, type 1; targeted mutation 1.2, Tadafumi Kato
• MGI ID: MGI:6779991
• Synonyms: NTRK1 E495K
• Gene: Ntrk1 Location: Chr3:87685551-87702469 bp, - strand Genetic Position: Chr3, 38.62 cM
• Alliance: Ntrk1^tm1.2Tkato page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:309176
• Parent Cell Line: CMTI-2 (ES Cell)
• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Targeted (Not Specified)
• Mutation: Insertion
• Mutation details: The targeting construct inserted into intron 12 a lox2272 site, inverted exon 12 containing the nucleotide substitutions that results in the amino acid substitution of aspartic acid with lysine at position 495 (E495K), a loxP site, a lox2272 site, and an FRT-flanked neomycin resistance cassette. Flp-mediated recombination removed the selection cassette. Cre-mediated recombination reverted the modified exon 12. (J:309176)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ntrk1 Mutation: 60 strains or lines available

References

• Original: J:309176 Nakajima K, et al., Ntrk1 mutation co-segregating with bipolar disorder and inherited kidney disease in a multiplex family causes defects in neuronal growth and depression-like behavior in mice. Transl Psychiatry. 2020 Nov 24;10(1):407
• All: 1 reference(s)