Drd1^{tm1(DRD1)Svek}
Targeted Allele Detail

Summary

• Symbol: Drd1^{tm1(DRD1)Svek}
• Name: dopamine receptor D1; targeted mutation 1, Kjell A Svensson
• MGI ID: MGI:6771697
• Gene: Drd1 Location: Chr13:54205202-54209677 bp, - strand Genetic Position: Chr13, 28.4 cM
• Alliance: Drd1^{tm1(DRD1)Svek} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:311565
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6NTac

Mutation description

• Allele Type: Targeted (Conditional ready, Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Drd1^{tm1(DRD1)Svek} expresses 1 gene
  Knock-in expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  DRD1 (1812)

  Drd1	(MGI:99578)

• Mutation details: The entire coding region in exon 2 was replaced with a floxed codon optimized human DRD1 cDNA and an FRT flanked neo cassette was inserted in intron 2 via homologous recombination. (J:311565)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Drd1 Mutation: 71 strains or lines available

References

• Original: J:311565 Svensson KA, et al., An Allosteric Potentiator of the Dopamine D1 Receptor Increases Locomotor Activity in Human D1 Knock-In Mice without Causing Stereotypy or Tachyphylaxis. J Pharmacol Exp Ther. 2017 Jan;360(1):117-128
• All: 3 reference(s)