Dct^tm1.1Enis
Targeted Allele Detail

Summary

• Symbol: Dct^tm1.1Enis
• Name: dopachrome tautomerase; targeted mutation 1.1, Emi K Nishimura
• MGI ID: MGI:6766470
• Synonyms: Dct-H2B-EGFP
• Gene: Dct Location: Chr14:118250202-118289656 bp, - strand Genetic Position: Chr14, 61.6 cM
• Alliance: Dct^tm1.1Enis page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:311103
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Inserted expressed sequence, Null/knockout, Reporter)
• Mutation: Insertion
• Mutation details: The C-terminus of the histone H2B fused to the EGFP reporter was inserted into the Dct gene exon1 via homologous recombination in ES cells. Cre-mediated recombination removed the neo cassette. (J:311103)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Dct Mutation: 35 strains or lines available

References

• Original: J:311103 Eshiba S, et al., Stem cell spreading dynamics intrinsically differentiate acral melanomas from nevi. Cell Rep. 2021 Aug 3;36(5):109492
• All: 1 reference(s)