Kdm7a^em3Jko
Endonuclease-mediated Allele Detail

Summary

• Symbol: Kdm7a^em3Jko
• Name: lysine (K)-specific demethylase 7A; endonuclease-mediated mutation 3, Keio University School of Medicine
• MGI ID: MGI:6766428
• Synonyms: Kdm7a^B6_4_del
• Gene: Kdm7a Location: Chr6:39113554-39183707 bp, - strand Genetic Position: Chr6, 17.87 cM
• Alliance: Kdm7a^em3Jko page

Mutation origin

• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: CRISPR-targeting of exon 6 produced a 4 bp deletion that introduced a frameshift and premature termination at the start of the jumonji C (JmjC) domain resulting in a predicted peptide length of 269 amino acids (J:308865)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Kdm7a Mutation: 50 strains or lines available

References

• Original: J:308865 Higashijima Y, et al., Lysine demethylase 7a regulates murine anterior-posterior development by modulating the transcription of Hox gene cluster. Commun Biol. 2020 Nov 30;3(1):725
• All: 1 reference(s)