Gt(ROSA)26Sor^{tm2(CAG-Cd274,-GFP)Tcw}
Targeted Allele Detail

Summary

• Symbol: Gt(ROSA)26Sor^{tm2(CAG-Cd274,-GFP)Tcw}
• Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 2, Timothy C Wang
• MGI ID: MGI:6766412
• Synonyms: R26-LSL-Pdl1-IRES-GFP
• Gene: Gt(ROSA)26Sor Location: Chr6:113044389-113054205 bp, - strand Genetic Position: Chr6, 52.73 cM
• Alliance: Gt(ROSA)26Sor^{tm2(CAG-Cd274,-GFP)Tcw} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:309365
• Parent Cell Line: KV1 (ES Cell)
• Strain of Origin: (C57BL/6J x 129S6/SvEvTac)F1

Mutation description

• Allele Type: Targeted (Conditional ready, Inserted expressed sequence, No functional change, Reporter)
• Mutation: Insertion
• Gt(ROSA)26Sor^{tm2(CAG-Cd274,-GFP)Tcw} expresses 1 gene
  Knock-in expresses:
  

  Organism	Expressed Gene	Note
  mouse	Cd274 (MGI:1926446)

• Mutation details: A construct consisting of a CAG promoter, floxed-stop cassette, mouse Cd274, IRES site, and EGFP was inserted between exons 1 and 2 via homologous recombination. (J:309365)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gt(ROSA)26Sor Mutation: 1062 strains or lines available

References

• Original: J:309365 Kim W, et al., PD-1 Signaling Promotes Tumor-Infiltrating Myeloid-Derived Suppressor Cells and Gastric Tumorigenesis in Mice. Gastroenterology. 2021 Feb;160(3):781-796
• All: 1 reference(s)