Cd200^{tm1c(KOMP)Wtsi}
Targeted Allele Detail

Summary

• Symbol: Cd200^{tm1c(KOMP)Wtsi}
• Name: CD200 molecule; targeted mutation 1c, Wellcome Trust Sanger Institute
• MGI ID: MGI:6766410
• Synonyms: Cd200^fl
• Gene: Cd200 Location: Chr16:45202498-45229416 bp, - strand Genetic Position: Chr16, 29.53 cM, cytoband A1
• Alliance: Cd200^{tm1c(KOMP)Wtsi} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:310826
• Parent Cell Line: JM8A1.N3 (ES Cell)
• Strain of Origin: C57BL/6N-A^tm1Brd

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: The L1L2_Bact_P cassette was inserted at position 45214682 of Chromosome 16 upstream of the critical exons 3 and 4 (Build GRCm39). The cassette is composed of an FRT site followed by lacZ sequence and a loxP site. This first loxP site is followed by a neomycin resistance gene under the control of the human beta-actin promoter, SV40 polyA, a second FRT site and a second loxP site. A third loxP site is inserted downstream of the targeted exons 3 and 4 at position 45218142. The critical exons 3 and 4 are thus flanked by loxP sites. Flp-mediated recombination removed the lacZ and neomycin resistance gene creating a "conditional ready" (floxed) allele. (J:310826)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cd200 Mutation: 28 strains or lines available

References

• Original: J:310826 Khan IZ, et al., The CD200-CD200R Axis Promotes Squamous Cell Carcinoma Metastasis via Regulation of Cathepsin K. Cancer Res. 2021 Jun 28
• All: 1 reference(s)