Pparg^tm2.1Tgen
Targeted Allele Detail

Summary

• Symbol: Pparg^tm2.1Tgen
• Name: peroxisome proliferator activated receptor gamma; targeted mutation 1.2, TransGenic
• MGI ID: MGI:6766395
• Synonyms: Pparg1sv^(exonC)tm1
• Gene: Pparg Location: Chr6:115337912-115467360 bp, + strand Genetic Position: Chr6, 53.41 cM, cytoband E3-F1
• Alliance: Pparg^tm2.1Tgen page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:311151
• Parent Cell Line: Bruce 4 (ES Cell)
• Strain of Origin: B6.Cg-Thy1^a

Mutation description

• Allele Type: Targeted (Modified isoform(s))
• Mutations: Insertion, Intragenic deletion
• Mutation details: An FRT flanked neo cassette and loxP site were inserted between exons A1 and C, and a loxP site was inserted downstream of exon C via homologous recombination. Recombinase mediated recombination removed the neo cassette and exon C leaving exon A1 in place. (J:311151)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pparg Mutation: 39 strains or lines available

References

• Original: J:311151 Nakano T, et al., Effects of Ppargamma1 deletion on late-stage murine embryogenesis and cells that undergo endocycle. Dev Biol. 2021 Oct;478:222-235
• All: 1 reference(s)