Papss2^tm1.1Wexi
Targeted Allele Detail

Summary

• Symbol: Papss2^tm1.1Wexi
• Name: 3'-phosphoadenosine 5'-phosphosulfate synthase 2; targeted mutation 1.1, Wen Xie
• MGI ID: MGI:6766354
• Synonyms: Papss2^fl
• Gene: Papss2 Location: Chr19:32573190-32644587 bp, + strand Genetic Position: Chr19, 27.46 cM
• Alliance: Papss2^tm1.1Wexi page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:311107
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: An FRT site, loxP site, neomycin cassette, FRT site, and second loxP site were inserted upstream of exon 3. A third loxP site was inserted downstream of exon 6. Flp-mediated recombination removed the neomycin cassette leaving exons 3-6 floxed. (J:311107)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Papss2 Mutation: 33 strains or lines available

References

• Original: J:311107 Xu P, et al., Intestinal Sulfation Is Essential to Protect Against Colitis and Colonic Carcinogenesis. Gastroenterology. 2021 Jul;161(1):271-286.e11
• All: 2 reference(s)