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Ghrem1Gokc
Endonuclease-mediated Allele Detail
Summary
Symbol: Ghrem1Gokc
Name: growth hormone receptor; endonuclease-mediated mutation 1, Omer Gokcumen
MGI ID: MGI:6765450
Gene: Ghr  Location: Chr15:3347237-3612834 bp, - strand  Genetic Position: Chr15, 1.84 cM
Alliance: Ghrem1Gokc page
Mutation
origin
Strain of Origin:  C57BL/6N
Mutation
description
Allele Type:    Endonuclease-mediated (Not Applicable)
Mutation:    Intragenic deletion
 
Mutation detailsCRISPR/cas9 genome editing is used to delete exon 3 (2.5 kb). Sequencing identified 12 variants (2 SNPs and 10 indels), none of the variants hit any known sequences. (J:317164)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Ghr Mutation:  50 strains or lines available
References
Original:  J:317164 Saitou M, et al., Sex-specific phenotypic effects and evolutionary history of an ancient polymorphic deletion of the human growth hormone receptor. Sci Adv. 2021 Sep 24;7(39):eabi4476
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
10/22/2024
MGI 6.24
The Jackson Laboratory