Pms2^tm1.1Sks
Targeted Allele Detail

Summary

• Symbol: Pms2^tm1.1Sks
• Name: PMS1 homolog2, mismatch repair system component; targeted mutation 1.1, Shyam Sharan
• MGI ID: MGI:6764550
• Synonyms: Pms2^c.1993AtoG, Pms2^ki
• Gene: Pms2 Location: Chr5:143846782-143870786 bp, + strand Genetic Position: Chr5, 82.82 cM, cytoband G2
• Alliance: Pms2^tm1.1Sks page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:310354
• Parent Cell Line: v6.4 (ES Cell)
• Strain of Origin: (C57BL/6J x 129S4/SvJae)F1

Mutation description

• Allele Type: Targeted (Hypomorph)
• Mutation: Single point mutation
• Mutation details: The targeting construct replaced exon 11 with on containing the point mutation A to G that deletes the last 5 bp of exon 11 from the transcript by introducing a premature stop codon (I665*). Cre-mediated recombination removed floxed neomycin selection cassette into intron 11. (J:310354)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pms2 Mutation: 50 strains or lines available

References

• Original: J:310354 Biswas K, et al., A novel mouse model of PMS2 founder mutation that causes mismatch repair defect due to aberrant splicing. Cell Death Dis. 2021 Sep 6;12(9):838
• All: 1 reference(s)