Klf1^tm1Ckjs
Targeted Allele Detail

Summary

• Symbol: Klf1^tm1Ckjs
• Name: Kruppel-like transcription factor 1 (erythroid); targeted mutation 1, C K James Shen
• MGI ID: MGI:6763975
• Synonyms: Eklf^-
• Gene: Klf1 Location: Chr8:85628611-85631920 bp, + strand Genetic Position: Chr8, 41.3 cM
• Alliance: Klf1^tm1Ckjs page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:306881
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Hypomorph)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Using homologous recombination in ES cells, an inverted loxP-PGK-gb2-neo-loxP cassette was inserted into the intron 1 region of the Klf1 gene to generate the hypomorphic allele. (J:306881)

Expression

In Mice Carrying this Mutation:

1 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Klf1 Mutation: 22 strains or lines available

References

• Original: J:306881 Hung CH, et al., Negative Regulation of the Differentiation of Flk2(-) CD34(-) LSK Hematopoietic Stem Cells by EKLF/KLF1. Int J Mol Sci. 2020 Nov 10;21(22):8448
• All: 2 reference(s)