Trp53bp1^tm1.1Nus
Targeted Allele Detail

Summary

• Symbol: Trp53bp1^tm1.1Nus
• Name: transformation related protein 53 binding protein 1; targeted mutation 1.1, Andre Nussenzweig
• MGI ID: MGI:6763420
• Synonyms: 53BP1^S25A
• Gene: Trp53bp1 Location: Chr2:121023762-121101888 bp, - strand Genetic Position: Chr2, 60.37 cM
• Alliance: Trp53bp1^tm1.1Nus page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:286257
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Not Applicable)
• Mutation: Single point mutation
• Mutation details: A T-to-G mutation was engineered in exon 2 to change serine codon 30 (TCT) to an alanine codon (GCT)(p.S30A), making that residue unphosphorylatable in the encoded peptide. The loxP site flanked neomycin resistance gene that was inserted into intron 1 was removed through subsequent cre-mediated recombination. (J:286257)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Trp53bp1 Mutation: 100 strains or lines available

References

• Original: J:286257 Callen E, et al., 53BP1 Enforces Distinct Pre- and Post-resection Blocks on Homologous Recombination. Mol Cell. 2020 Jan 2;77(1):26-38.e7
• All: 2 reference(s)