Rhbdf2^em2Anlu
Endonuclease-mediated Allele Detail

Summary

• Symbol: Rhbdf2^em2Anlu
• Name: rhomboid 5 homolog 2; endonuclease-mediated mutation 2, Andreas Ludwig
• MGI ID: MGI:6763377
• Synonyms: iRhom2^Del
• Gene: Rhbdf2 Location: Chr11:116488991-116517786 bp, - strand Genetic Position: Chr11, Syntenic
• Alliance: Rhbdf2^em2Anlu page

Mutation origin

• Strain of Origin: Not Applicable

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: CRISPR/Cas9-mediated mutagenesis created a deletion of 13 nucleotides positioned directly before iRhom Conserved ER to Golgi Export Sequence (iCERES) resulting in an early translational stop. (J:310482)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rhbdf2 Mutation: 84 strains or lines available

References

• Original: J:310482 Dusterhoft S, et al., The iRhom homology domain is indispensable for ADAM17-mediated TNFalpha and EGF receptor ligand release. Cell Mol Life Sci. 2021 Jun;78(11):5015-5040
• All: 1 reference(s)