Tlr9^tm1.2Kmiy
Targeted Allele Detail

Summary

• Symbol: Tlr9^tm1.2Kmiy
• Name: toll-like receptor 9; targeted mutation 1.2, Kensuke Miyake
• MGI ID: MGI:6763175
• Synonyms: Tlr9^-
• Gene: Tlr9 Location: Chr9:106099797-106104075 bp, + strand Genetic Position: Chr9, 57.46 cM
• Alliance: Tlr9^tm1.2Kmiy page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:280157
• Parent Cell Line: JM8A1.N3 (ES Cell)
• Strain of Origin: C57BL/6N-A^tm1Brd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site was inserted into intron 1 and a second loxP site and an FRT site flanked neomycin resistance gene cassette downstream of a modified exon 2 where 13 codons (HPAPLSTPASKNF) had been deleted. The neo cassette was removed through subsequent flp-mediated recombination. Exon 2 was deleted through subsequent cre-mediated recombination. (J:280157)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tlr9 Mutation: 63 strains or lines available

References

• Original: J:280157 Fukui R, et al., Cleavage of Toll-Like Receptor 9 Ectodomain Is Required for In Vivo Responses to Single Strand DNA. Front Immunol. 2018;9:1491
• All: 1 reference(s)