Unc93b1^tm2.2Kmiy
Targeted Allele Detail

Summary

• Symbol: Unc93b1^tm2.2Kmiy
• Name: unc-93 homolog B1, TLR signaling regulator; targeted mutation 2.2, Kensuke Miyake
• MGI ID: MGI:6763173
• Synonyms: Unc93b1^-
• Gene: Unc93b1 Location: Chr19:3985222-3999340 bp, + strand Genetic Position: Chr19, 3.65 cM
• Alliance: Unc93b1^tm2.2Kmiy page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:280157
• Parent Cell Line: JM8A1.N3 (ES Cell)
• Strain of Origin: C57BL/6N-A^tm1Brd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site was inserted into intron 1 and a second loxP site and an FRT site flanked neomycin resistance gene into intron 3. The neo cassette was removed through subsequent flp-mediated recombination and exons 2 and 3 were deleted through subsequent cre-mediated recombination. (J:280157)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Unc93b1 Mutation: 41 strains or lines available

References

• Original: J:280157 Fukui R, et al., Cleavage of Toll-Like Receptor 9 Ectodomain Is Required for In Vivo Responses to Single Strand DNA. Front Immunol. 2018;9:1491
• All: 2 reference(s)