Trp53^tm1.1Itl
Targeted Allele Detail

Summary

• Symbol: Trp53^tm1.1Itl
• Name: transformation related protein 53; targeted mutation 1.1, Ingenious Targeting Laboratory
• MGI ID: MGI:6763106
• Synonyms: p53^N236S, p53^S
• Gene: Trp53 Location: Chr11:69471185-69482699 bp, + strand Genetic Position: Chr11, 42.83 cM, cytoband B2-C
• Alliance: Trp53^tm1.1Itl page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:283471
• Parent Cell Line: iTL BA1 (ES Cell)
• Strain of Origin: (C57BL/6NTac x 129S6/SvEvTac)F1

Mutation description

• Allele Type: Targeted (Humanized sequence)
• Mutation: Single point mutation
• Mutation details: An A-to-G point mutation (c.707A>G) was engineered in exon 7 to change asparagine codon 236 to a serine codon (p.N236S). The loxP site flanked neomycin resistance gene cassette that was inserted into intron 11 was removed through subsequent cre-mediated recombination. The mutation is found in some human tumors and some tumorigenic mouse cell lines. (J:283471)

Tumor Data

List all tumor models in MMHCdb carrying Trp53^tm1.1Itl

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Trp53 Mutation: 237 strains or lines available

References

• Original: J:283471 Zhao L, et al., Gain of function in the mouse model of a recurrent mutation p53(N236S) promotes the formation of double minute chromosomes and the oncogenic potential of p19(ARF). Mol Carcinog. 2018 Feb;57(2):147-158
• All: 3 reference(s)