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Ace2em2Guru
Endonuclease-mediated Allele Detail
Summary
Symbol: Ace2em2Guru
Name: angiotensin I converting enzyme (peptidyl-dipeptidase A) 2; endonuclease-mediated mutation 2, Channabasavaiah Gurumurthy
MGI ID: MGI:6763025
Synonyms: mAce2KI-82M
Gene: Ace2  Location: ChrX:162922338-162971414 bp, + strand  Genetic Position: ChrX, 76.12 cM, cytoband F5
Alliance: Ace2em2Guru page
Mutation
origin
Strain of Origin:  C57BL/6J
Mutation
description
Allele Type:    Endonuclease-mediated (Humanized sequence)
Mutation:    Nucleotide substitutions
 
Mutation detailsCRISPR/cas9 endonuclease-mediated genome editing is used to insert an amino acid substitution at position 82 altering serine to methionine (S82M - AGT to ATG) . The mutation is designed to partially humanize the mouse Ace2 coding sequence in a region important for binding to the SARS-CoV-2 spike protein. (J:101977)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Ace2 Mutation:  36 strains or lines available
References
Original:  J:298750 Gurumurthy CB, et al., Genetically modified mouse models to help fight COVID-19. Nat Protoc. 2020 Dec;15(12):3777-3787
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/22/2022
MGI 6.22
The Jackson Laboratory