S100a4^em1Ysfk
Endonuclease-mediated Allele Detail

Summary

• Symbol: S100a4^em1Ysfk
• Name: S100 calcium binding protein A4; endonuclease-mediated mutation 1, Yoshinori Fukui
• MGI ID: MGI:6762164
• Synonyms: S100a4^-
• Gene: S100a4 Location: Chr3:90511077-90513349 bp, + strand Genetic Position: Chr3, 39.27 cM, cytoband F1-F2
• Alliance: S100a4^em1Ysfk page

Mutation origin

• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: Using CRISPR/Cas9 system, the exon 2 of mouse S100a4 was targeted to induce 7 bp deletion. This deletion leads to frame-shift in the last amino acid sequence encoded by exon 2, and results in a premature stop codon in exon 3. (J:299945)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any S100a4 Mutation: 24 strains or lines available

References

• Original: J:299945 Kunimura K, et al., S100A4 Protein Is Essential for the Development of Mature Microfold Cells in Peyer's Patches. Cell Rep. 2019 Nov 26;29(9):2823-2834.e7
• All: 1 reference(s)