Optn^tm1Hkawa
Targeted Allele Detail

Summary

• Symbol: Optn^tm1Hkawa
• Name: optineurin; targeted mutation 1, Hideshi Kawakami
• MGI ID: MGI:6762162
• Synonyms: Optn KO
• Gene: Optn Location: Chr2:5025453-5068862 bp, - strand Genetic Position: Chr2, 3.15 cM
• Alliance: Optn^tm1Hkawa page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:300212
• Parent Cell Line: TT2 (ES Cell)
• Strain of Origin: (C57BL/6NCrlj x CBA/JNCrlj)F1

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The exon 810 of the Optn gene was replaced with a neomycin cassette (Neo) flanked by loxP sites via homologous recombination in ES cells. The absence of Optn protein in the homozygous mice were confirmed by immunoblotting of the lumbar spinal cords. (J:300212)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Optn Mutation: 48 strains or lines available

References

• Original: J:300212 Kurashige T, et al., Optineurin defects cause TDP43-pathology with autophagic vacuolar formation. Neurobiol Dis. 2021 Jan;148:105215
• All: 3 reference(s)