C1qtnf12^tm1Nou
Targeted Allele Detail

Summary

• Symbol: C1qtnf12^tm1Nou
• Name: C1q and tumor necrosis factor related 12; targeted mutation 1, Noriyuki Ouchi
• MGI ID: MGI:6762160
• Synonyms: APL-KO
• Gene: C1qtnf12 Location: Chr4:156046775-156051086 bp, + strand Genetic Position: Chr4, 87.66 cM
• Alliance: C1qtnf12^tm1Nou page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:301118
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A part of exon 1 through a part of exon 4 was replaced with loxP franked neo cassette via homologous recombination in ES cells disrupting the gene. The absence of C1qtnf12 mRNA in adipose tissue and protein levels in serum in homozygous mice. (J:301118)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any C1qtnf12 Mutation: 20 strains or lines available

References

• Original: J:301118 Ogawa H, et al., Adipolin/CTRP12 protects against pathological vascular remodelling through suppression of smooth muscle cell growth and macrophage inflammatory response. Cardiovasc Res. 2020 Jan 1;116(1):237-249
• All: 3 reference(s)