Lrig1^tm1Hhed
Targeted Allele Detail

Summary

• Symbol: Lrig1^tm1Hhed
• Name: leucine-rich repeats and immunoglobulin-like domains 1; targeted mutation 1, Hakan Hedman
• MGI ID: MGI:6762158
• Gene: Lrig1 Location: Chr6:94581510-94677139 bp, - strand Genetic Position: Chr6, 43.15 cM
• Alliance: Lrig1^tm1Hhed page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:310228
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 1 and a neomycin resistance gene cassette and a second loxP site were inserted into intron 1. This creates a conditional-ready allele with exon 1 floxed. (J:310228)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Lrig1 Mutation: 51 strains or lines available

References

• Original: J:310228 Mao F, et al., Lrig1 is a haploinsufficient tumor suppressor gene in malignant glioma. Oncogenesis. 2018 Feb 2;7(2):13
• All: 1 reference(s)