Oga^tm1.1Jaha
Targeted Allele Detail

Summary

• Symbol: Oga^tm1.1Jaha
• Name: O-GlcNAcase; targeted mutation 1.1, John A Hanover
• MGI ID: MGI:6761311
• Gene: Oga Location: Chr19:45738698-45772274 bp, - strand Genetic Position: Chr19, 38.75 cM, cytoband D1
• Alliance: Oga^tm1.1Jaha page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:250414
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site was inserted upstream of exon 1, and a second loxP site, FRT-flanked neomycin selection cassette and third loxP site were inserted downstream of exon 1. Cre-mediated recombination removed exon 1 but left the neomycin selection cassette. (J:250414)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Oga Mutation: 51 strains or lines available

References

• Original: J:250414 Keembiyehetty C, et al., Conditional knock-out reveals a requirement for O-linked N-Acetylglucosaminase (O-GlcNAcase) in metabolic homeostasis. J Biol Chem. 2015 Mar 13;290(11):7097-113
• All: 1 reference(s)