Hoxa5^{em1.1(cre)Fmr}
Endonuclease-mediated Allele Detail

Summary

• Symbol: Hoxa5^{em1.1(cre)Fmr}
• Name: homeobox A5; endonuclease-mediated mutation 1.1, Filippo M Rijli
• MGI ID: MGI:6759846
• Synonyms: Hoxa5::Cre
• Gene: Hoxa5 Location: Chr6:52178768-52181437 bp, - strand Genetic Position: Chr6, 25.4 cM
• Alliance: Hoxa5^{em1.1(cre)Fmr} page

Mutation origin

• Strain of Origin: C57BL/6 x BALB/c

Mutation description

• Allele Type: Endonuclease-mediated (Recombinase)
• Mutation: Insertion
• Hoxa5^{em1.1(cre)Fmr} expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Hoxa5 (MGI:96177)

• Mutation details: Using CRISPR/Cas9 system, a Cre-FRT-Neo-FRT cassette was inserted into the mouse Hoxa5 ATG codon. The neo cassette was excised by mating with Flpe deleted mice. (J:306314)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Hoxa5 (mouse) Summary of all recombinase alleles driven by Hoxa5. Alliance mouse Hoxa5 gene page

Expression

In Mice Carrying this Mutation:

1 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Hoxa5 Mutation: 27 strains or lines available

References

• Original: J:306314 Maheshwari U, et al., Postmitotic Hoxa5 Expression Specifies Pontine Neuron Positional Identity and Input Connectivity of Cortical Afferent Subsets. Cell Rep. 2020 Jun 16;31(11):107767
• All: 1 reference(s)