Asic1^em1Cibms
Endonuclease-mediated Allele Detail

Summary

• Symbol: Asic1^em1Cibms
• Name: acid-sensing ion channel 1; endonuclease-mediated mutation 1, Chih-Cheng Chen
• MGI ID: MGI:6759765
• Synonyms: Asic1b^-
• Gene: Asic1 Location: Chr15:99568249-99599011 bp, + strand Genetic Position: Chr15, 56.13 cM, cytoband F3
• Alliance: Asic1^em1Cibms page

Mutation origin

• Strain of Origin: Not Specified

Mutation description

• Allele Type: Endonuclease-mediated (Modified isoform(s))
• Mutation: Intragenic deletion
• Mutation details: Using CRISPR/Cas9 technology, the alternatively spliced exon containing the ATG translation start codon of a splicing variant of Asic1, ASIC1b was deleted. The resulting allele express Asic1a isoform but not Asic1b. (J:309655)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Asic1 Mutation: 44 strains or lines available

References

• Original: J:309655 Chang CT, et al., Involvement of Acid-Sensing Ion Channel 1b in the Development of Acid-Induced Chronic Muscle Pain. Front Neurosci. 2019;13:1247
• All: 2 reference(s)