Krt8^tm1.1Leu
Targeted Allele Detail

Summary

• Symbol: Krt8^tm1.1Leu
• Name: keratin 8; targeted mutation 1.1, Rudolf E Leube
• MGI ID: MGI:6759469
• Synonyms: Krt8-YFP
• Gene: Krt8 Location: Chr15:101905146-101912777 bp, - strand Genetic Position: Chr15, 57.2 cM
• Alliance: Krt8^tm1.1Leu page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:309696
• Parent Cell Line: HM-1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd-Hprt1^b-m3

Mutation description

• Allele Type: Targeted (Reporter)
• Mutation: Insertion
• Mutation details: The YFP gene was inserted in-frame before the stop codon in exon 9 and an FRT site flanked neomycin resistance gene cassette was inserted downstream. The neo cassette was removed through subsequent flp-mediated recombination, leaving a chimeric Krt8/YFP gene. (J:309696)

Expression

In Mice Carrying this Mutation:

1 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Krt8 Mutation: 30 strains or lines available

References

• Original: J:309696 Schwarz N, et al., Dissection of keratin network formation, turnover and reorganization in living murine embryos. Sci Rep. 2015 Mar 11;5:9007
• All: 4 reference(s)