Olig1^{tm1.1(cre)Rth}
Targeted Allele Detail

Summary

• Symbol: Olig1^{tm1.1(cre)Rth}
• Name: oligodendrocyte transcription factor 1; targeted mutation 1.1, David H Rowitch
• MGI ID: MGI:6759440
• Synonyms: Olig1^Cre
• Gene: Olig1 Location: Chr16:91066660-91068821 bp, + strand Genetic Position: Chr16, 52.67 cM
• Alliance: Olig1^{tm1.1(cre)Rth} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:309618
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout, Recombinase)
• Mutations: Insertion, Intragenic deletion
• Olig1^{tm1.1(cre)Rth} expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Olig1 (MGI:1355334)

• Mutation details: The majority of the coding region for this gene was replaced with a cre-neo cassette via homologous recombination so that the cre coding sequence is joined in-frame to the endogenous gene's coding region immediately following the translation initiation site. The neo selection cassette was removed from the parental Olig1^tm1(cre)Rth allele. (J:75868, J:309618)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Olig1 (mouse) Summary of all recombinase alleles driven by Olig1. Alliance mouse Olig1 gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Olig1 Mutation: 13 strains or lines available

References

• Original: J:309618 Jiang M, et al., WNT signaling suppresses oligodendrogenesis via Ngn2-dependent direct inhibition of Olig2 expression. Mol Brain. 2020 Nov 13;13(1):155
• All: 5 reference(s)