Ube2i^tm1.1Wgcy
Targeted Allele Detail

Summary

• Symbol: Ube2i^tm1.1Wgcy
• Name: ubiquitin-conjugating enzyme E2I; targeted mutation 1.1, Cong-Yi Wang
• MGI ID: MGI:6759407
• Synonyms: Ubc9^f
• Gene: Ube2i Location: Chr17:25479482-25493856 bp, - strand Genetic Position: Chr17, 12.53 cM
• Alliance: Ube2i^tm1.1Wgcy page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:261571
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: The targeting construct introduced a loxP site upstream of exon 2 and an FRT-flanked neomycin resistance cassette with a 3 loxP site downstream of exon 4. Flp-mediated recombination removed the selection cassette and left exons 2 through 4 floxed. (J:261571)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ube2i Mutation: 22 strains or lines available

References

• Original: J:261571 He X, et al., Both conditional ablation and overexpression of E2 SUMO-conjugating enzyme (UBC9) in mouse pancreatic beta cells result in impaired beta cell function. Diabetologia. 2018 Apr;61(4):881-895
• All: 5 reference(s)