Mlkl^em2Mpa
Endonuclease-mediated Allele Detail

Summary

• Symbol: Mlkl^em2Mpa
• Name: mixed lineage kinase domain-like; endonuclease-mediated mutation 2, Manolis Pasparakis
• MGI ID: MGI:6758929
• Synonyms: Mlkl-
• Gene: Mlkl Location: Chr8:112038429-112064809 bp, - strand Genetic Position: Chr8, 57.98 cM, cytoband D3
• Alliance: Mlkl^em2Mpa page

Mutation origin

• Strain of Origin: Not Specified

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: CRISPR/Cas9 genome editing technology was used to generate a mutation in the Mlkl gene by microinjected with Mlkl short guiding (sg)RNA and Cas9 mRN into the pronucleus of fertilized oocytes obtained from breedings of K14-Cre; Ripk1fl/wt males with Ripk1fl/fl females. (J:217312)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mlkl Mutation: 34 strains or lines available

References

• Original: J:217312 Dannappel M, et al., RIPK1 maintains epithelial homeostasis by inhibiting apoptosis and necroptosis. Nature. 2014 Sep 4;513(7516):90-4
• All: 3 reference(s)