Diaph2^{tm1(CAG-Cflar)Hna}
Targeted Allele Detail

Summary

• Symbol: Diaph2^{tm1(CAG-Cflar)Hna}
• Name: diaphanous related formin 2; targeted mutation 1, Hiroyasu Nakano
• MGI ID: MGI:6758920
• Synonyms: CFLARs Tg
• Gene: Diaph2 Location: ChrX:128650491-129366583 bp, + strand Genetic Position: ChrX, 52.36 cM
• Alliance: Diaph2^{tm1(CAG-Cflar)Hna} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:286073
• Parent Cell Line: KTPU8 (ES Cell)
• Strain of Origin: (C57BL/6NCrlj x CBA/JNCrlj)F1

Mutation description

• Allele Type: Targeted (Epitope tag, Inserted expressed sequence)
• Mutations: Disruption caused by insertion of vector, Insertion
• Mutation details: RMCE of Diaph2^{Gt(Ayu21-B210)Imeg} inserted a FLAG tagged mouse Cflar gene under the control of the CAG promoter followed by puromycin selection cassette. (J:286073)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Diaph2 Mutation: 58 strains or lines available

References

• Original: J:286073 Shindo R, et al., Necroptosis of Intestinal Epithelial Cells Induces Type 3 Innate Lymphoid Cell-Dependent Lethal Ileitis. iScience. 2019 May 31;15:536-551
• All: 1 reference(s)