Rheb^tm1Rfl
Targeted Allele Detail

Summary

• Symbol: Rheb^tm1Rfl
• Name: Ras homolog enriched in brain; targeted mutation 1, Richard F Lamb
• MGI ID: MGI:6758256
• Synonyms: Rheb1^fl
• Gene: Rheb Location: Chr5:25007821-25047359 bp, - strand Genetic Position: Chr5, 11.93 cM
• Alliance: Rheb^tm1Rfl page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:306412
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted into intron 2 and a second loxP site into intron 3, creating a conditional-ready allele with exon 3 floxed. (J:306412)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rheb Mutation: 25 strains or lines available

References

• Original: J:306412 Xiao B, et al., Rheb1-Independent Activation of mTORC1 in Mammary Tumors Occurs through Activating Mutations in mTOR. Cell Rep. 2020 Apr 28;31(4):107571
• All: 2 reference(s)