Vav2tm1.1Geno
Targeted Allele Detail
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Symbol: |
Vav2tm1.1Geno |
Name: |
vav 2 oncogene; targeted mutation 1.1, Genoway |
MGI ID: |
MGI:6758212 |
Synonyms: |
Vav2f |
Gene: |
Vav2 Location: Chr2:27152116-27317045 bp, - strand Genetic Position: Chr2, 19.36 cM
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Alliance: |
Vav2tm1.1Geno page
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Germline Transmission: |
Earliest citation of germline transmission:
J:290809
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Parent Cell Line: |
Not Specified (ES Cell)
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Strain of Origin: |
Not Specified
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Allele Type: |
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Targeted (Conditional ready, No functional change) |
Mutations: |
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Insertion, Nucleotide substitutions
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Mutation details: The targeting mutation inserted a lox511 site upstream of the endogenous exon 11 and an FRT-flanked neomycin resistance cassette inserted downstream of exon 11 followed by a floxed and inverted exon 11 with the amino acid substitution of leucine with alanine at position 332 (L332A) and a lox511 site. Flp-mediated recombination removed the FRT-flanked neomycin resistance cassette.
(J:290809)
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Vav2 Mutation: |
45 strains or lines available
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Original: |
J:290809 Lorenzo-Martin LF, et al., Vav2 pharmaco-mimetic mice reveal the therapeutic value and caveats of the catalytic inactivation of a Rho exchange factor. Oncogene. 2020 Jul;39(28):5098-5111 |
All: |
1 reference(s) |
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