B2m^tm1.1Rdf
Targeted Allele Detail

Summary

• Symbol: B2m^tm1.1Rdf
• Name: beta-2 microglobulin; targeted mutation 1.1, Riccardo Dalla-Favera
• MGI ID: MGI:6757224
• Gene: B2m Location: Chr2:121978168-121983563 bp, + strand Genetic Position: Chr2, 60.55 cM, cytoband F1-F3
• Alliance: B2m^tm1.1Rdf page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:306418
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S/SvEv

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: An FRT site flanked neomycin resistance gene cassette and a loxP site were inserted into intron 1 and a second loxP site into intron 3. The neo cassette was removed through subsequent flp-mediated recombination, leaving a conditional-ready allele with exons 2-3 floxed. (J:306418)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any B2m Mutation: 122 strains or lines available

References

• Original: J:306418 Fangazio M, et al., Genetic mechanisms of HLA-I loss and immune escape in diffuse large B cell lymphoma. Proc Natl Acad Sci U S A. 2021 Jun 1;118(22):e2104504118
• All: 1 reference(s)