Sptbn4^tm1.1Geno
Targeted Allele Detail

Summary

• Symbol: Sptbn4^tm1.1Geno
• Name: spectrin beta, non-erythrocytic 4; targeted mutation 1.1, Genoway
• MGI ID: MGI:6757187
• Synonyms: Spnb4^fl
• Gene: Sptbn4 Location: Chr7:27055808-27147111 bp, - strand Genetic Position: Chr7, 15.88 cM, cytoband A3
• Alliance: Sptbn4^tm1.1Geno page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:270357
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: LoxP sites were inserted into the gene flanking exons 29 and 30. A neomycin selection cassette was removed via recombination. (J:270357)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Sptbn4 Mutation: 121 strains or lines available

References

• Original: J:270357 Unudurthi SD, et al., betaIV-Spectrin regulates STAT3 targeting to tune cardiac response to pressure overload. J Clin Invest. 2018 Dec 3;128(12):5561-5572
• All: 7 reference(s)