Obscn^tm2.1Geno
Targeted Allele Detail

Summary

• Symbol: Obscn^tm2.1Geno
• Name: obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF; targeted mutation 2.1, Genoway
• MGI ID: MGI:6757167
• Synonyms: Obscn-deltaIg58/59
• Gene: Obscn Location: Chr11:58885082-59027201 bp, - strand Genetic Position: Chr11, 36.4 cM
• Alliance: Obscn^tm2.1Geno page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:302919
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Not Specified)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP-FRT-neomycin-FRT cassette was inserted upstream of exon 60 and a second loxP site was inserted downstream of exon 61. Cre-mediated recombination removed the neomycin cassette and deleted exons 60 and 61, which contain the immunoglobulin domains 58/59. (J:302919)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Obscn Mutation: 420 strains or lines available

References

• Original: J:302919 Grogan A, et al., Deletion of obscurin immunoglobulin domains Ig58/59 leads to age-dependent cardiac remodeling and arrhythmia. Basic Res Cardiol. 2020 Sep 10;115(6):60
• All: 1 reference(s)