Tg(tetO-d2EGFP,-Shh)#Ohts
Transgene Detail

Summary

• Symbol: Tg(tetO-d2EGFP,-Shh)#Ohts
• Name: transgene insertion, Toshiyuki Ohtsuka
• MGI ID: MGI:6756396
• Synonyms: TRE-mShh/d2EGFP
• Transgene: Tg(tetO-d2EGFP,-Shh)#Ohts Location: unknown
• Alliance: Tg(tetO-d2EGFP,-Shh)#Ohts page

Transgene origin

• Strain of Origin: Not Applicable

Transgene description

• Transgene Type: Transgenic (Inducible, Inserted expressed sequence, Reporter)
• Inducer: doxycycline/tetracycline
• Mutation: Insertion
• Tg(tetO-d2EGFP,-Shh)#Ohts expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Shh (MGI:98297)

• Mutation details: In this construct, the tetO tetracycline responsive element (TRE) was placed between the modified d2EGFP reporter gene and the mouse sonic hedgehog cDNA. The two genes are arranged in opposite transcriptional orientation (head-to-head) and the SV40 poly(A) signal sequence was placed 3' of each. (J:306455)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:306455 Shqirat M, et al., Sonic hedgehog expands neural stem cells in the neocortical region leading to an expanded and wrinkled neocortical surface. Genes Cells. 2021 Jun;26(6):399-410
• All: 2 reference(s)