Gt(ROSA)26Sor^{tm7(CAG-FGF13A)Smoc}
Targeted Allele Detail

Summary

• Symbol: Gt(ROSA)26Sor^{tm7(CAG-FGF13A)Smoc}
• Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 7, Shanghai Model Organisms Center
• MGI ID: MGI:6755502
• Synonyms: Gt(ROSA)26Sor(CAG-hFGF13A)
• Gene: Gt(ROSA)26Sor Location: Chr6:113044389-113054205 bp, - strand Genetic Position: Chr6, 52.73 cM
• Alliance: Gt(ROSA)26Sor^{tm7(CAG-FGF13A)Smoc} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:306679
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, Humanized sequence, Inserted expressed sequence, No functional change)
• Mutation: Insertion
• Mutation details: A cassette comprising the following elements was inserted into the locus: CAG promoter, loxP site flanked neomycin resistance gene cassette, human FGF13A cDNA, woodchuck hepatitis virus posttranscriptional regulatory element (WPRE) sequence and poly(A) signal sequence. Only after cre-mediated deletion of the neo cassette will this allele express FGF13A. (J:306679)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gt(ROSA)26Sor Mutation: 1060 strains or lines available

References

• Original: J:306679 Yang QQ, et al., Nuclear isoform of FGF13 regulates post-natal neurogenesis in the hippocampus through an epigenomic mechanism. Cell Rep. 2021 May 18;35(7):109127
• All: 1 reference(s)