Slc12a5^tm3.1Geno
Targeted Allele Detail

Summary

• Symbol: Slc12a5^tm3.1Geno
• Name: solute carrier family 12, member 5; targeted mutation 3.1, Genoway
• MGI ID: MGI:6755483
• Synonyms: KCC2^E
• Gene: Slc12a5 Location: Chr2:164802766-164841651 bp, + strand Genetic Position: Chr2, 85.28 cM, cytoband G2-G3
• Alliance: Slc12a5^tm3.1Geno page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:281008
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129/Sv

Mutation description

• Allele Type: Targeted (Not Applicable)
• Mutation: Nucleotide substitutions
• Mutation details: A threonine to glutamate substitution at amino acid 906 (T906E) and a threonine to glutamate substitution at amino acid 1007 (T1007E) were inserted into exons 22 and 24, respectively. A loxP-flanked neomycin selection cassette inserted between exons 22 and 23 was removed via cre-mediated recombination. (J:281008)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Slc12a5 Mutation: 46 strains or lines available

References

• Original: J:281008 Pisella LI, et al., Impaired regulation of KCC2 phosphorylation leads to neuronal network dysfunction and neurodevelopmental pathology. Sci Signal. 2019 Oct 15;12(603)
• All: 2 reference(s)