Ptprc^em6Lutzy
Endonuclease-mediated Allele Detail

Summary

• Symbol: Ptprc^em6Lutzy
• Name: protein tyrosine phosphatase receptor type C; endonuclease-mediated mutation 6, Cathy Lutz
• MGI ID: MGI:6753365
• Synonyms: JAXBoy, Ptprc^K302E
• Gene: Ptprc Location: Chr1:137990599-138103446 bp, - strand Genetic Position: Chr1, 60.73 cM
• Alliance: Ptprc^em6Lutzy page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Not Applicable)
• Mutation: Nucleotide substitutions
• Mutation details: CRISPR/cas9 genome editing is used to alter a lysine to glutamic acid mutation at amino acid 302 (K302E ; AAA to GAA) in exon 10. Additionally, the silent nucleotide change N303N (AAC to AAT) was included for targeting efficiency. The substitution results in the expression of Ptprc^a (CD45.1 or Ly5.1) rather than the Ptprc^b (CD45.2 or Ly5.2) allele normally expressed by C57BL/6J mice. (J:101977)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Ptprc Mutation: 212 strains or lines available

References

• Original: J:101977 The Jackson Laboratory, Information obtained from The Jackson Laboratory, Bar Harbor, ME. Unpublished. 2005-2017
• All: 29 reference(s)