Cnr1^tm1.1Mars
Targeted Allele Detail

Summary

• Symbol: Cnr1^tm1.1Mars
• Name: cannabinoid receptor 1; targeted mutation 1.1, Giovanni Marsicano
• MGI ID: MGI:6750932
• Synonyms: DN22-CB1-KI
• Gene: Cnr1 Location: Chr4:33924593-33948831 bp, + strand Genetic Position: Chr4, 16.28 cM
• Alliance: Cnr1^tm1.1Mars page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:306938
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Not Applicable)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP flanked STOP cassette and Cnr1 sequence lacking the first 22 amino acids replaced the wild-type coding sequence. Cre-mediated recombination excised the STOP cassette. qRT-PCR and immunofluorescence shows no differences in mRNA and protein expression in different brain regions, however the density of mitochondria-associated protein is reduced. (J:306938)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cnr1 Mutation: 42 strains or lines available

References

• Original: J:306938 Soria-Gomez E, et al., Subcellular specificity of cannabinoid effects in striatonigral circuits. Neuron. 2021 May 5;109(9):1513-1526.e11
• All: 4 reference(s)