Tg(Igh-Myc)#Yde
Transgene Detail

Summary

• Symbol: Tg(Igh-Myc)#Yde
• Name: transgene insertion, Yves Denizot
• MGI ID: MGI:6741555
• Synonyms: c-myc-3'LCR
• Transgene: Tg(Igh-Myc)#Yde Location: unknown
• Alliance: Tg(Igh-Myc)#Yde page

Transgene origin

• Germline Transmission: Earliest citation of germline transmission: J:131646
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Igh-Myc)#Yde expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Myc (MGI:97250)	mouse gene (with its own promoters) with mouse Igh LCR sequence downstream

• Mutation details: Genomic fragments containing mouse Igh 3' regulatory regions hs3a, hs1,2, hs3b and hs4 were placed downstream (in their endogenous order) of a mouse Myc gene cassette (comprising genomic sequence for Myc promoters P1 and P2 and all exons and introns). The entire construct was flanked by chicken beta globin HS4 insulator sequences to promote position independent and copy number dependent regulation of the inserted gene by the regulatory regions. (J:131646)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:131646 Truffinet V, et al., The 3' IgH locus control region is sufficient to deregulate a c-myc transgene and promote mature B cell malignancies with a predominant Burkitt-like phenotype. J Immunol. 2007 Nov 1;179(9):6033-42
• All: 6 reference(s)