Avil^{tm1.1(flpo)Ddg}
Targeted Allele Detail

Summary

• Symbol: Avil^{tm1.1(flpo)Ddg}
• Name: advillin; targeted mutation 1.1, David D Ginty
• MGI ID: MGI:6740440
• Synonyms: Advillin^FlpO
• Gene: Avil Location: Chr10:126836578-126856863 bp, + strand Genetic Position: Chr10, 74.48 cM, cytoband D3
• Alliance: Avil^{tm1.1(flpo)Ddg} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:290819
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Recombinase)
• Mutation: Insertion
• Avil^{tm1.1(flpo)Ddg} expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Avil (MGI:1333798)

• Mutation details: A Flpo recombinase cassettes were introduced via homologous recombination into the Avil genes, replacing the first coding ATG. The recombinase is driven by Avil in somatosensory and other peripheral nervous system neurons. The neomycin selection cassette was removed by recombination. (J:290819, J:297417)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Avil (mouse) Summary of all recombinase alleles driven by Avil. Comparative matrix view of recombinase activities Alliance mouse Avil gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Avil Mutation: 46 strains or lines available

References

• Original: J:290819 Neubarth NL, et al., Meissner corpuscles and their spatially intermingled afferents underlie gentle touch perception. Science. 2020 Jun 19;368(6497)
• All: 7 reference(s)