Oprm1^tm1.1Ygs
Targeted Allele Detail

Summary

• Symbol: Oprm1^tm1.1Ygs
• Name: opioid receptor, mu 1; targeted mutation 1.1, Yan-Gang Sun
• MGI ID: MGI:6739850
• Synonyms: Oprm1^fl
• Gene: Oprm1 Location: Chr10:6708593-6988209 bp, + strand Genetic Position: Chr10, 1.85 cM, cytoband A2
• Alliance: Oprm1^tm1.1Ygs page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:291061
• Parent Cell Line: Other (see notes) (ES Cell)
• Strain of Origin: 129S6/SvEv

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: A targeting vector was designed to insert a frt-flanked neomycin (neo) resistance cassette and loxP upstream of exon 2 of the mouse opioid receptor (Oprm1) gene. The construct was electroporated into 129S6/SvEv -derived embryonic stem (ES) cells SCR012. The resulting mice were crossed with FRT recombinase expression mice to delete the neo cassette. This mouse strain enables the Cre-mediated deletion of exon 2 and exon 3. (J:291061)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Oprm1 Mutation: 55 strains or lines available

References

• Original: J:291061 Zhang XY, et al., Different neuronal populations mediate inflammatory pain analgesia by exogenous and endogenous opioids. Elife. 2020 Jun 10;9:e55289
• All: 1 reference(s)