Vwf^{tm1.1(VWF)Scr}
Targeted Allele Detail

Summary

• Symbol: Vwf^{tm1.1(VWF)Scr}
• Name: Von Willebrand factor; targeted mutation 1.1, The Scripps Research Institute
• MGI ID: MGI:6730098
• Synonyms: VWF^h28
• Gene: Vwf Location: Chr6:125529911-125663642 bp, + strand Genetic Position: Chr6, 59.32 cM
• Alliance: Vwf^{tm1.1(VWF)Scr} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:270490
• Parent Cell Line: E14TG2a.4 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Vwf^{tm1.1(VWF)Scr} expresses 1 gene
  Knock-in expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  VWF (7450)

  Vwf	(MGI:98941)

  expresses human exon 28

• Mutation details: The endogenous exon 28 was replaced with the human exon 28. The loxP site flanked neomycin resistance gene cassette that was inserted into intron 28 was removed through subsequent Cre-mediated recombination. (J:270490)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Vwf Mutation: 139 strains or lines available

References

• Original: J:270490 Kanaji S, et al., Humanized GPIbalpha-von Willebrand factor interaction in the mouse. Blood Adv. 2018 Oct 9;2(19):2522-2532
• All: 2 reference(s)