Gt(ROSA)26Sor^tm1(Relb)Rie
Targeted Allele Detail

Summary

• Symbol: Gt(ROSA)26Sor^tm1(Relb)Rie
• Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 1, Marc Riemann
• MGI ID: MGI:6729309
• Synonyms: Rosa26-Relb
• Gene: Gt(ROSA)26Sor Location: Chr6:113044389-113054205 bp, - strand Genetic Position: Chr6, 52.73 cM
• Alliance: Gt(ROSA)26Sor^tm1(Relb)Rie page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:270571
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Conditional ready, Inserted expressed sequence)
• Mutation: Insertion
• Mutation details: By homologous recombination in ES cells, a murine Relb cDNA was inserted into the locus downstream of a floxed STOP cassette. The cre recombinase expression in the cell will remove the floxed STOP cassette driving ubiquitous Relb expression. (J:270571)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gt(ROSA)26Sor Mutation: 1095 strains or lines available

References

• Original: J:270571 Riemann M, et al., Central immune tolerance depends on crosstalk between the classical and alternative NF-kappaB pathways in medullary thymic epithelial cells. J Autoimmun. 2017 Jul;81:56-67
• All: 2 reference(s)